PT-141

Description

Overview

PT-141, also known as Bremelanotide, is a cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH). It acts primarily as an agonist at melanocortin receptors MC3R and MC4R located in the central nervous system. In research settings, PT-141 is used to study neuroendocrine signaling, receptor activation, and neural pathways that influence sexual behavior, appetite regulation, and energy metabolism.

Unlike other peptide hormones that act peripherally, PT-141’s effects are mediated through direct activation of central melanocortin receptors, making it an important molecule for studying neuropeptide function and CNS receptor modulation.

Product Details

• Peptide Type: Melanocortin receptor agonist (MC3R/MC4R)
• Structure: Cyclic heptapeptide analogue of α-MSH
• Molecular Weight: ~1451.6 g/mol
• Purity: Research-grade (≥ 98 %)
• Regulatory Status: Laboratory research use only; not approved for therapeutic or veterinary use
• CAS Number: 189691-06-3

Research Applications

• Neuroendocrine & CNS Studies: Used to investigate central melanocortin receptor activation and its role in sexual behavior, mood regulation, and neuropeptide signaling.
• Metabolic & Appetite Regulation: Studied in preclinical models to assess how MC4R/MC3R activation affects appetite suppression, fat metabolism, and energy expenditure.
• Receptor Pharmacology Research: Serves as a selective model compound for evaluating peptide-receptor binding, cyclic structure stability, and CNS pharmacodynamics.
• Peptide Engineering & Stability: Valuable in studies examining cyclic peptide design, half-life optimization, and bioavailability improvements in neuroactive peptides.

Usage & Safety

This product is intended for laboratory research use only. It is not approved for human or veterinary use, and must not be used for diagnostic, therapeutic, or cosmetic purposes. Proper laboratory safety procedures and storage protocols should always be followed when handling this material.

Disclaimer

All information provided is for educational and scientific research purposes only. This material is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary consumption.