MOTS-c

Description

Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-type C) is a naturally occurring mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It acts as a signalling molecule that can translocate to the nucleus under metabolic stress, where it regulates gene expression, activates AMPK pathways, and supports overall metabolic balance.

In research contexts, MOTS-c has been shown to influence mitochondrial function, glucose metabolism, lipid oxidation, and stress adaptation, making it a key target for studies exploring energy homeostasis and aging.

Product Details

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Peptide Length: 16 amino acids
• Mechanism Highlights: Activates AMPK signalling, supports mitochondrial-nuclear communication, enhances lipid and glucose metabolism, and regulates cellular stress response.
• Research Status: Supplied for laboratory research use only; not approved for therapeutic, diagnostic, or veterinary applications.
• CAS Number: 1627580-64-6

Research Applications

• Metabolism & Insulin Sensitivity: Used in models examining how MOTS-c improves glucose uptake, mitochondrial function, and insulin responsiveness.
• Exercise & Mitochondrial Function: Studied as an exercise-responsive peptide that influences energy regulation and metabolic adaptation.
• Aging & Stress Response: Explored for its potential to modulate cellular stress pathways and counteract age-related metabolic decline.
• Lipid Metabolism & Fat Oxidation: Utilized in research on mitochondrial fat regulation and metabolic signalling associated with energy expenditure.

Usage & Safety

This compound is intended for laboratory research use only. It is not approved for human or veterinary use and should not be used for diagnostic, therapeutic, or cosmetic applications. Handle under appropriate lab safety and storage conditions.

Disclaimer

All information provided is for educational and scientific research purposes only. This material is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary consumption.