HMG

Description

Overview

HMG (Human Menopausal Gonadotropin, also known as menotropin) is a glycoprotein hormone preparation derived from the urine of postmenopausal women, containing a combination of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity. Like other members of the glycoprotein hormone family, it is composed of a shared alpha subunit and a hormone-specific beta subunit.

In research settings, HMG is employed as a tool to study folliculogenesis, gonadal steroidogenesis, and hypothalamic-pituitary-gonadal axis signalling.

Product Details

• Type: Glycoprotein hormone preparation (FSH/LH activity)
• Typical Molecular Weight: ~30 kDa (per subunit hormone)
• Mechanism: Activates FSH and LH receptors on gonadal tissue to stimulate follicular development and steroidogenic enzyme pathways.
• Research Status: Provided for laboratory research use only; not approved for therapeutic, diagnostic or veterinary use.
• Typical Format: Lyophilized vial, highly purified, suitable for in-vitro and preclinical models.
• CAS Number: 9002-68-0

Research Applications

• Gonadotropin Receptor Signalling: Used in studies of FSH/LH receptor activation, intracellular cAMP production, and steroidogenic enzyme up-regulation.
• Folliculogenesis Modelling: Employed to examine follicular growth and maturation in cell and animal models.
• Steroidogenesis Assays: Utilised in investigations of granulosa and theca cell function, estrogen/progesterone biosynthesis, and receptor-agonist kinetics.
• Glycoprotein Hormone Structure & Mechanism Research: Serves as a model for exploring glycosylation and receptor binding kinetics shared across the LH/FSH/TSH/hCG hormone family.

Usage & Safety

This material is intended for laboratory research use only. It is not approved for human or veterinary use, and should not be used for therapeutic, diagnostic, cosmetic or supplement purposes. Handle in compliance with institutional laboratory safety protocols and store under recommended peptide/hormone storage conditions (typically ≤ -20 °C for lyophilized material).

Disclaimer

All information provided herein is for educational and scientific research purposes only. This material is not intended to diagnose, treat, cure or prevent any disease. Not for human or veterinary consumption.